Intravenous Immunoglobulin Therapy

Important information:

Intravenous immunoglobulin (IVIG) therapy is a medical treatment that involves your child receiving a concentrated solution of immunoglobulins (antibodies), administered directly into their bloodstream through an intravenous (IV) infusion. It is used to boost the immune system in patients with certain medical conditions. These immunoglobulins are obtained from processed plasma of thousands of healthy donors and contain antibodies to help your child’s immune system function properly.

How is IVIG administered?

IVIG is administered through a slow intravenous infusion, usually over 3-4 hours, and is always administered by a nurse. It may be given at a hospital or clinic, or in some cases, your child can receive treatment at home with a homecare nurse.

What follow up is needed?

Follow-up visits and lab draws every 6 months are important to assess the treatment’s effectiveness, adjust the dosage if needed, and address any concerns or side effects.

What are the side effects?

IVIG therapy can have side effects, which may include:

• Headache

• Fever

• Chills

• Nausea

• Muscle pain

More severe reactions are rare but can occur, such as:

• Anaphylaxis

• Kidney damage

• Aseptic meningitis (neck stiffness, fever, visual sensitivity)

Your child will be closely monitored during treatment to manage and prevent adverse effects. If your child develops mild symptoms during the infusion, premedication, such as cetirizine or acetaminophen, can often be given.

How does this work with insurance?

There are many brands used for IVIG therapy, and all brands are equally effective. Your insurance may determine what brand is used. Because of the different solutions in each therapy, some may work better than others and cause fewer side effects for your child’s body. Often, insurance carriers require certain brands to be tried first. We will work to ensure we use the best brand for your child. It is important to communicate any side effects your child experiences to your child’s treatment team, to ensure infusions are as comfortable as possible.

Reviewed April 2024 by Mary Mattaliano BSN RN CPN