Immunoglobulin Therapy: Subcutaneous vs. Intravenous

Important information:

There are many considerations when choosing the right type of therapy. 

Both types of immunoglobulin therapy:

• Provide the antibodies needed to help protect you, and both are equally effective.

• Require regular follow-ups and lab work.

• Require and insurance authorization process before starting.

Subcutaneous therapy (SCIG):

• Is typically given every week.

• Is administered at home.

• Uses 1-4 needle sites. 

• Is self-infused with education.

• Maintains steady levels if antibodies.

• Has few incidences of serious infusion reaction.

Intravenous therapy (IVIG):

• Is typically given every 4 weeks.

• Can be administered either in a facility or at home.

• Uses one needed site.

• Is always administered by a nurse.

• Can be given as a large antibody boost.

• Has greater opportunity for infusion reaction.

Reviewed April 2024 by Mary Mattaliano, BSN, RN, CPN